Daily supplements rich in vitamin E tocotrienols may boost the immune response and immune function in healthy women following a vaccination.
According to findings published in the European Journal of Clinical Nutrition, women who received daily supplements of a palm tocotrienol complex for one month prior to a single tetanus toxoid (TT) vaccine experienced improvements in their immune response, compared with women who received placebo prior to the vaccine.
Tocotrienols are a form of vitamin E that have traditionally been in the shadow of the more popular vitamin E form—tocopherols.
Overall, there are eight forms of vitamin E: four tocopherols (alpha, beta, gamma, delta) and four tocotrienols (alpha, beta, gamma, delta). Alpha-tocopherol (alpha-Toc) is the main source found in supplements and in the European diet, while gamma-tocopherol (gamma-Toc) is the most common form in the American diet.
Tocotrienols (TCT) are only minor components in plants, although several sources with relatively high levels include palm oil, cereal grains and rice bran.
To test the effects of the tocotrienol-rich palm fraction on immune function, Malaysia-based scientists recruited 108 healthy non-smoking women aged between 18 and 25 years. The women were randomly split into two groups: One group received 400 mg of the palm tocotrienol complex per day, and the other group received placebo (400 mg per day of soy oil), each for two months.
Blood samples were analyzed at the start of the study, and again after 28 and 56 days. After 28 days of supplementation all of the participants received a single shot of tetanus toxoid vaccine.
Results showed significant increases in levels of the anti-TT antibody, interferon (IFN)-gamma and interleukin (IL)-4 in the tocotrienol group, compared with placebo.
“This study provides evidence that daily supplementation of 400 mg tocotrienol-rich fraction can have a beneficial role in enhancing the immune response of healthy subjects following an immunogenic challenge such as vaccination,” stated the researchers.
Furthermore, blood levels of tocotrienols increased, compared with placebo, with the greatest increases in alpha-T3, followed by gamma-T3 and delta-T3.
This study was conducted using Carotech's Tocomin SupraBio - patented and bioenhanced palm tocotrienol complex.
ReplyDeleteThe Tocomin®SupraBio™ System is a patented and bio-enhanced natural full spectrum palm tocotrienol complex. It guarantees an increase in absorption of tocotrienols by an average of 250% the circulatory system compared to any regular tocotrienol oil extract.
Most fat-soluble phytonutrients (including the regular tocopherol vitamin E) and antioxidants are poorly absorbed, which will result in poor bioavailability. Thus consumers are not getting the optimal benefits or it takes a longer period of supplementation to see the health effects / benefits.
Hovid (Carotech's parent company), one of the largest GMP-certified pharmaceutical has had many years of experience in bio-equivalence studies - a regulatory requirement for registering and production of generic drugs. One of Hovid's specialties is to ensure that those generic drugs are bio-equivalent to the original drug. We collaborate with the University Science of Malaysia - USM (School of Pharmaceutical Sciences).
As a result of this research collaboration with USM, we have developed a unique and the most bioavailable tocotrienol system in the world - Tocomin®SupraBio™ System. Due to its uniqueness and cutting edge technology, it has been awarded a US Patent - US Patent No : 6.596,306.
Tocomin®SupraBio™ System has the following unique properties :-
i.An average of 250% increase in absorption (2 period, 2 sequence crossover human study). Hence, achieving therapeutic level in bloodstream or higher blood level at the same dosage of supplementation.
ii.Consistent & Rapid absorption
iii.Promotes absorption of tocotrienols via lymphatic system as well.
iv.Does not depend on dietary fat intake / food
v.Ensures a rapid transport of tocotrienols into the blood. Faster to reach maximum peak
References :-
i)Pharmacokinetics and bioavailability of alpha-, gamma- and delta-tocotrienol under different food status, J. of Pharmacy and Pharmacology, 2001, 53 : 67-71.
ii)Influence of route of administration on the absorption and disposition of a-, g – and d-tocotrienol, J. of Pharmacy and Pharmacology, 2003, 55 : 53-58
iii)US Patent No : US 6,596,306; July 22 2003
iv)Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations, Intl. J. of Pharmaceutics, 2004, (281); 67-78
Tocomin®SupraBio™ is produced with Carotech's natural tocotrienol extract - Tocomin®. It is and will be the most bioavailable tocotrienol complex in the market.
I would also like to invite you to visit the leading educational website for tocotrienol : www.tocotrienol.org . This website is dedicated to the dissemination of information about tocotrienol to the general public/consumers.
Follow Carotech's latest research updates on our Facebook page and main company website:
www.carotech.net
www.facebook.com/CarotechInc
This study was conducted using Carotech's Tocomin SupraBio - patented and bioenhanced palm tocotrienol complex.
ReplyDeleteThe Tocomin®SupraBio™ System is a patented and bio-enhanced natural full spectrum palm tocotrienol complex. It guarantees an increase in absorption of tocotrienols by an average of 250% the circulatory system compared to any regular tocotrienol oil extract.
Most fat-soluble phytonutrients (including the regular tocopherol vitamin E) and antioxidants are poorly absorbed, which will result in poor bioavailability. Thus consumers are not getting the optimal benefits or it takes a longer period of supplementation to see the health effects / benefits.
Hovid (Carotech's parent company), one of the largest GMP-certified pharmaceutical has had many years of experience in bio-equivalence studies - a regulatory requirement for registering and production of generic drugs. One of Hovid's specialties is to ensure that those generic drugs are bio-equivalent to the original drug. We collaborate with the University Science of Malaysia - USM (School of Pharmaceutical Sciences).
As a result of this research collaboration with USM, we have developed a unique and the most bioavailable tocotrienol system in the world - Tocomin®SupraBio™ System. Due to its uniqueness and cutting edge technology, it has been awarded a US Patent - US Patent No : 6.596,306.
Tocomin®SupraBio™ System has the following unique properties :-
i.An average of 250% increase in absorption (2 period, 2 sequence crossover human study). Hence, achieving therapeutic level in bloodstream or higher blood level at the same dosage of supplementation.
ii.Consistent & Rapid absorption
iii.Promotes absorption of tocotrienols via lymphatic system as well.
iv.Does not depend on dietary fat intake / food
v.Ensures a rapid transport of tocotrienols into the blood. Faster to reach maximum peak
References :-
i)J. of Pharmacy and Pharmacology, 2001, 53 : 67-71.
ii) J. of Pharmacy and Pharmacology, 2003, 55 : 53-58
iii)US Patent No : US 6,596,306; July 22 2003
iv)Intl. J. of Pharmaceutics, 2004, (281); 67-78
Tocomin®SupraBio™ is produced with Carotech's natural tocotrienol extract - Tocomin®. It is and will be the most bioavailable tocotrienol complex in the market.
I would also like to invite you to visit the leading educational website for tocotrienol : www.tocotrienol.org . This website is dedicated to the dissemination of information about tocotrienol to the general public/consumers.
Follow Carotech's latest research updates on our Facebook page and main company website:
www.carotech.net
www.facebook.com/CarotechInc